ICSI (Intracytoplasmic Sperm Injection) in Cyprus

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ICSI (Intracytoplasmic Sperm Injection) in Cyprus

Infertility is an issue that affects millions of couples worldwide, making assisted reproductive technologies (ART) a crucial development in modern medicine. One of the most effective treatments available today is ICSI (Intracytoplasmic Sperm Injection), a specialized form of IVF (In Vitro Fertilization) that significantly increases the chances of fertilization. Cyprus has emerged as a top destination for couples seeking ICSI treatment, offering advanced fertility clinics, expert specialists, and high success rates. This guide provides an in-depth look at ICSI IVF, covering its process, benefits, success rates, and why Cyprus is a preferred choice.

What is ICSI Treatment?

ICSI is a procedure where a single sperm is directly injected into an egg, bypassing many natural fertilization barriers. This technique is particularly beneficial for couples dealing with male infertility, unexplained infertility, or recurrent IVF failures. Unlike traditional IVF, where sperm and egg are left to fertilize naturally in a lab dish, ICSI IVF ensures sperm reaches the egg successfully.

How is ICSI Different from Traditional IVF?

The primary difference between ICSI vs IVF is how fertilization occurs. In conventional IVF, eggs and sperm are combined in a laboratory dish, allowing natural fertilization. In contrast, ICSI treatment involves manually selecting and injecting a single sperm into the egg. This significantly increases the chances of fertilization, particularly in cases where sperm quality is poor.

Why is ICSI Used in Infertility Treatments?

ICSI is a preferred fertility treatment when traditional IVF is not effective. It is commonly used for:

  • Male infertility, including low sperm count, poor motility, or abnormal sperm shape.
  • Unexplained infertility, where no clear reason for infertility is found.
  • Recurrent IVF failures, helping couples who have undergone multiple unsuccessful IVF attempts.

icsi in cyprusThe ICSI Process

The ICSI procedure follows a series of carefully controlled steps to maximize the chances of fertilization and pregnancy.

Step-by-Step Procedure for ICSI

  • Ovarian Stimulation: The woman undergoes hormone treatments to stimulate her ovaries to produce multiple eggs.
  • Egg Retrieval: Eggs are collected from the ovaries using a minor surgical procedure called follicular aspiration, which is guided by ultrasound.
  • Sperm Collection and Preparation: A sperm sample is obtained from the male partner or a donor. If necessary, sperm is retrieved surgically in cases of severe male infertility.
  • Sperm Selection: The healthiest, most motile sperm are identified using advanced laboratory techniques to ensure the best possible fertilization outcomes.
  • ICSI Procedure: A single sperm is carefully injected directly into each mature egg using a fine glass needle under a microscope.
  • Embryo Culture and Monitoring: The fertilized eggs (now embryos) are monitored for several days in a specialized incubator to track their development.
  • Embryo Transfer: Once the embryos reach the appropriate stage of development (typically day 3 or day 5), one or more embryos are transferred into the woman’s uterus.
  • Luteal Phase Support: Hormonal medications are prescribed to help support implantation and early pregnancy.
  • Pregnancy Test: A blood test is performed about two weeks after the embryo transfer to determine if implantation has occurred successfully.
  • Embryo Transfer: One or more embryos are transferred to the uterus.
  • Pregnancy Test: A blood test is conducted two weeks after the transfer.

How are Sperm and Eggs Prepared for ICSI?

Preparation of sperm and eggs is crucial for ensuring successful fertilization.

  • Egg Preparation: Once retrieved, eggs are assessed for maturity. Only mature eggs are used for ICSI as they have the best chance of fertilization.
  • Sperm Preparation: The sperm sample is washed and processed to isolate the most viable sperm. If necessary, sperm is obtained through testicular or epididymal aspiration (TESE or PESA).
  • Injection Process: The selected sperm is immobilized and injected directly into the cytoplasm of the egg to ensure fertilization.
  • Embryo Assessment: After injection, the fertilized eggs are cultured in a controlled environment and observed for successful cell division and quality grading before transfer.

Who is ICSI Suitable for?

ICSI is particularly beneficial for couples facing specific fertility challenges that prevent natural conception or success with traditional IVF. The following groups are the most suitable candidates for ICSI:

Male Infertility and ICSI

Male infertility is one of the most common reasons couples turn to ICSI fertility treatment. It provides a highly effective solution for cases where sperm abnormalities prevent natural fertilization. Some of the key male infertility factors that can be overcome with ICSI include:

  • Low sperm count (oligospermia): When a man produces fewer sperm than normal, natural conception may be difficult. ICSI ensures that even a very limited number of sperm can be used for fertilization.
  • Poor sperm motility (asthenozoospermia): Sperm must be able to move efficiently to reach and fertilize an egg. If motility is low, ICSI eliminates this issue by directly injecting the sperm into the egg.
  • Abnormal sperm shape (teratozoospermia): When sperm have structural abnormalities, they may be unable to penetrate the egg naturally. ICSI bypasses this problem by selecting the best-quality sperm and injecting them into the egg.
  • Previous vasectomy or obstructive issues: Men who have undergone a vasectomy or have a blockage in the reproductive tract may not have sperm present in their ejaculate. In such cases, sperm can be surgically retrieved and used for ICSI.
  • DNA fragmentation in sperm: High levels of DNA fragmentation in sperm can lead to embryo development issues. ICSI helps in selecting the healthiest sperm with minimal DNA damage, improving the chances of a successful pregnancy.
  • Cases requiring surgical sperm retrieval: Some men have non-obstructive azoospermia (no sperm in ejaculate due to production issues), requiring sperm extraction directly from the testes through procedures like TESE (testicular sperm extraction) or PESA (percutaneous epididymal sperm aspiration). ICSI enables fertilization with these retrieved sperm.

By directly injecting sperm into the egg, ICSI IVF success rates are significantly improved in cases of male infertility, giving couples a better chance of achieving pregnancy.

Unexplained Infertility Cases

In some couples, standard fertility tests do not reveal a clear cause for infertility. This condition, known as unexplained infertility, can be frustrating and challenging. Despite normal sperm parameters, ovulation cycles, and fallopian tube patency, conception does not occur naturally. In such cases, In Vitro Fertilization (IVF) with Intracytoplasmic Sperm Injection (ICSI) can significantly enhance the chances of conception by ensuring direct fertilization of the egg, thereby eliminating fertilization as a potential barrier.

ICSI for Recurrent IVF Failures

Couples who have experienced multiple failed IVF cycles may benefit from ICSI, as it provides a higher chance of fertilization by overcoming barriers at the sperm-egg interaction level. ICSI involves injecting a single, high-quality sperm directly into the egg, ensuring fertilization even when past IVF cycles have resulted in poor fertilization rates.

Who Should Consider ICSI for Recurrent IVF Failures?

  • Couples with previous IVF cycles that resulted in low or failed fertilization.
  • Patients diagnosed with severe male factor infertility (low sperm count, poor motility, or abnormal morphology).
  • Couples experiencing repeated implantation failures despite good embryo quality.
  • Those with potential egg quality concerns that may impact sperm-egg interaction.

Using ICSI in these scenarios helps ensure that sperm successfully penetrates the egg, leading to a higher likelihood of viable embryo formation and increasing the chances of a successful pregnancy.

ICSI Success Rates and Factors

The success rate of ICSI varies based on multiple factors, including patient age, sperm and egg quality, and the expertise of the fertility clinic performing the procedure.

Key Factors Affecting ICSI Success:

  • Maternal Age: Women under 35 typically have higher success rates, while success rates decline with increasing maternal age.
  • Sperm Quality: While ICSI can overcome sperm motility and morphology issues, extremely poor sperm DNA quality may still affect fertilization and embryo development.
  • Egg Quality: High-quality eggs improve the chances of successful fertilization and embryo viability.
  • Embryo Development: The ability of an embryo to reach the blastocyst stage significantly impacts implantation success.
  • Clinic Expertise: The laboratory’s equipment, embryologist skill, and overall clinic experience in performing ICSI influence outcomes.

What is the Success Rate of ICSI?

The ICSI treatment success rate typically ranges between 50% to 80% per cycle, depending on individual circumstances and clinic-specific results.

Breakdown of ICSI Success Rates Per Cycle:

  • Fertilization Rate: 70%–90% of eggs injected with sperm fertilize successfully.
  • Embryo Transfer Success Rate: Around 50%–60% of transferred embryos result in pregnancy.
  • Live Birth Rate: Typically ranges from 30%–50% per cycle, influenced by maternal age and embryo quality.

While ICSI significantly improves fertilization, overall pregnancy success also depends on embryo health and successful implantation. Advanced techniques such as Preimplantation Genetic Testing (PGT) may further improve success rates by selecting genetically normal embryos for transfer.

Factors Affecting ICSI Success

  • Age of the Woman: Younger women generally have higher ICSI percentage success due to better egg quality.
  • Sperm Quality: Although ICSI aids fertilization, very poor sperm quality may still impact embryo development.
  • Embryo Quality: Stronger embryos lead to higher implantation and pregnancy rates.
  • Fertility Clinic Expertise: Experienced specialists and cutting-edge technology greatly influence success rates.

Advantages of ICSI Treatment

ICSI offers several distinct benefits, making it a preferred IVF with ICSI method for many couples.

Overcoming Male Infertility Challenges

One of the most significant advantages of ICSI is its ability to help couples where male infertility is a major factor. Many men with low sperm count, poor motility, or abnormal sperm shape struggle with natural conception. ICSI ensures that even men with severe sperm deficiencies can father a biological child, as only a single healthy sperm is needed for each egg.

Increasing the Chances of Fertilization

Compared to conventional IVF, ICSI has a much higher fertilization rate because the sperm is directly injected into the egg, eliminating issues related to sperm movement or penetration. This is especially beneficial for couples who have had poor fertilization rates in previous IVF cycles.

ICSI allows embryologists to select the best-quality sperm, reducing the likelihood of using sperm with genetic defects. This increases the chances of developing high-quality embryos, which are more likely to implant successfully and lead to a healthy pregnancy.

Since ICSI significantly increases the fertilization rate, it also contributes to improved overall pregnancy rates, particularly for couples facing repeated IVF failures. This treatment ensures that the best embryos are transferred, giving a better chance of successful implantation.

For couples who have undergone extensive fertility testing but have not been given a clear reason for their infertility, ICSI fertility treatment provides a solution by guaranteeing fertilization. This eliminates one of the possible barriers to conception and improves their chances of a successful pregnancy.

Cost of ICSI Treatment 

The cost of ICSI fertility treatment can vary significantly based on factors such as the clinic’s expertise, location, additional procedures, and medication requirements. Although Cyprus is known for offering high-quality fertility treatments at more affordable rates than many Western countries, costs can differ depending on individual patient needs.

 

Why Choose Cyprus for ICSI?

Cyprus has become an attractive destination for Intracytoplasmic Sperm Injection (ICSI) fertility treatment due to its cutting-edge reproductive technologies, world-class specialists, and high success rates. Patients from around the world seek treatment in Cyprus for its affordability, confidentiality, and advanced medical facilities.

Cutting-edge Technology and Expertise

Fertility clinics in Cyprus are equipped with state-of-the-art medical technology, ensuring that patients receive the highest standard of care. Some key technological advancements include:

  • Advanced Embryo Monitoring: Time-lapse imaging systems track embryo development, selecting the most viable embryos for transfer.
  • Preimplantation Genetic Testing (PGT): Ensures only chromosomally normal embryos are selected, increasing implantation rates.
  • Micromanipulation Techniques: Enhance sperm injection accuracy, boosting fertilization success.
  • Cryopreservation Options: High-quality freezing techniques ensure optimal embryo survival for future cycles.

These innovations contribute to higher success rates and a better overall experience for patients seeking ICSI treatment in Cyprus.

Experienced Fertility Specialists

Cyprus boasts some of the most renowned fertility doctors and embryologists with extensive experience in reproductive medicine. The expertise of these specialists provides several advantages:

  • Personalized treatment plans tailored to each patient’s medical history and fertility needs.
  • Expert handling of complex fertility cases, including male factor infertility and recurrent IVF failures.
  • Multilingual support, allowing international patients to communicate with ease throughout the process.

With highly trained medical professionals leading treatments, Cyprus is a preferred location for couples seeking successful ICSI outcomes.

High Success Rates in Vita Altera IVF

The Cyprus IVF clinic at Vita Altera IVF is known for its outstanding ICSI pregnancy success rates, making it a top choice for international patients. Some contributing factors to its success include:

  • Personalized Fertility Care: Tailored protocols that optimize outcomes based on individual medical history.
  • Strict Quality Control Measures: Ensuring embryos are developed under optimal laboratory conditions.
  • Supportive Environment: Offering emotional and psychological support throughout the treatment journey.

Vita Altera IVF has built a reputation for excellence, attracting patients from Europe, the Middle East, and beyond. With success rates surpassing many international fertility centers, it remains a leader in assisted reproductive technology.

Frequently Asked Questions About ICSI

Does ICSI affect embryo quality? 

ICSI does not harm embryo quality when performed by experienced specialists.

Does ICSI cause autism? 

There is no scientific proof that ICSI directly causes autism.

Does ICSI cause birth defects? 

ICSI has a slightly higher risk of birth defects than natural conception, though the absolute risk remains low.

Does ICSI damage the egg? 

There is a minimal risk of egg damage, but skilled embryologists significantly reduce this possibility.

Does ICSI guarantee fertilization? 

No, but it significantly improves the chances of fertilization compared to standard IVF.

Does ICSI have higher success rates? 

Yes, ICSI success rates are higher than traditional IVF in cases of severe male infertility.

Does ICSI help with DNA fragmentation?

ICSI can bypass some issues related to sperm DNA fragmentation by selecting the best sperm.

Does ICSI improve embryo quality? 

ICSI increases fertilization but does not necessarily improve embryo quality.

Does ICSI improve fertilization rates? 

Yes, ICSI increases fertilization rates, especially in cases of male infertility.

Does ICSI increase IVF success? 

ICSI improves IVF outcomes in male infertility cases.

Does ICSI increase the chance of twins? 

ICSI does not directly increase twin rates, but transferring multiple embryos may result in twins.

Does ICSI work the first time? 

Many couples achieve pregnancy in their first ICSI cycle, but success depends on individual factors.

ICSI has revolutionized fertility treatments, helping couples overcome infertility challenges. Cyprus is a top destination for ICSI fertility treatment, offering expert specialists and cutting-edge technology. If you are struggling with infertility, consulting a Cyprus IVF clinic may be your first step toward parenthood.