Genetic Diagnosis – PGD


In some cases, the cause of the infertility problem may be congenital genetic problems in male, female or both. In addition, sometimes even if the couple is fertile, genetic analysis may be required for in vitro fertilization and embryos in order to obtain a healthy baby due to the genetic defects they carry. Although it is controversial, PGD may be an alternative for the couple in recurrent IVF failure.

Two types of testing and biopsy timing are possible in this method; initially biopsy testing and research can be done on 3-days old or 5-days old embryos. In addition, two different tests related to the disorder to be screened, FISH and NGS, may be recommended for the couple. All of these are started by making the necessary preparations before starting the treatment (for the screening of some genetic disorders, the genetic laboratory may need to take a blood sample from the couple in advance and make a preparation that can take 1-2 months). Some special diseases can be carried depending on the gender chromosome (such as hemophilia) and therefore embryo’s gender may be important for disease screening. However, the most important point that the couple should know is that the gender of the embryo is determined by the fertilizing sperm during the in vitro fertilization process, but we still do not have a method in which we can know beforehand whether the genetic load carried by the sperm is male or female and can select sperm accordingly. Therefore, after such a procedure, all embryos may come out as undesired gender or unhealthy.